Pacific Russia is regarded as an aquaterritorial macroregion in the composition of the Far Eastern Federal District and the adjacent sea area within the 200-nautical mile Exclusive Economic Zone. The macroregion harbors enormous natural land and sea resource wealth potential and is endowed with possibilities of using the sea transport connecting Russia and Europe with countries of the Asia-Pacific Region. In Pacific Russia, two latitudinal zones, northern and southern, are identified; they include the territories of the constituent entities of the Far Eastern Federal District. Combinations of the kinds of activity for the constituent entities and latitudinal zones are treated as territorial structures of the economy. An assessment of the geographical differentiation of the economy in the latitudinal zones for the years 2004 and 2013 and its change was made from the differences of the homogeneous kinds of activity in the constituent entities measured in terms of the added value. Structural gradients of spatial (including latitudinal) differentiation of the homogeneous kinds of economic activity are suggested for neighboring constituent entities. The analysis made for the latitudinal zones can be useful in assessing the variants of investment in the economy of the constituent entities of Pacific Russia.Keywords: spatial differentiation, latitudinal economic zones, territorial structures of the economy, structural gradients, added value, main kinds of activity.